Catherine Fleck-Vidal

PhD thesis:

Quantifying the impact of vaccination against enteric pathogens on AMR: real-world evidence from an LMIC setting

Antimicrobial resistance is one of the major challenges facing global health, particularly in low- and middle-income countries. Vaccines are increasingly recognised as a potential part of the response: they prevent infections and can reduce the need for antibiotics and, in turn, help limit the emergence and spread of resistance. Yet we still have limited empirical evidence on the impact of vaccination on AMR, making it difficult to assess its potential contribution to tackling AMR.

My PhD will investigate this question using evidence from a vaccine trial in a low- and middle-income country. I will explore how vaccination affects AMR outcomes, how its impact can be better measured, and how research evidence can be translated into policy. More broadly, I hope to understand how vaccines can contribute to tackling AMR and how this potential can be better reflected in national and global health strategies.

Who or what inspired you to pursue your research interests?

My interest in the impact of vaccination on antimicrobial resistance first developed through my work at the International Vaccine Institute. I particularly enjoyed the combination of scientific research, policy and international collaboration that this area involves, including working with colleagues at the WHO, in the Philippines, and elsewhere. 
My mentor Dr. Laura Plant played an important role in this journey; her enthusiasm and early support encouraged me to explore the field further and pursue doctoral research. I am excited to investigate how the impact of vaccination on AMR can be better quantified and reflected in global health policy.